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Granulation Systems

  • Compact Granulation System CGS

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    Compact Granulation System CGS
    Large image of Compact Granulation System CGS
    • Product Code:

      GCLIN-DICGS

    • The Diosna CGS (Compact Granulation System) is state of the art granulation production in the world's most compact, flexible and integrated plant.

      The CGS system is engineered from the ground up to optimize yield and operator ergonomics. The results are very impressive and have given the Pharmaceutical Industry a new leading standard in excellence of design.

      The CGS system design advantage is in close coupling technology developed by Diosna, which reduces the transfer distances between all processes while optimizing each of those processes though various techniques. The results speak for themselves: higher product yields, easiest access for inspection and cleaning, smallest installation in process room, improved GMPs throughout process train and simplified process. Validation though one highly integrated 21 CFR Part 11 control system.

      Processes offered:

      • Dry mixing/wet granulating/hot melt granulating/vacuum drying (with gas stripping aka "one pot processing"), 
      • Wet calibrating of product (milling) using quadro comil or similar conical screen mill, 
      • Fluid bed drying/top spray granulating/bottom or tangential spray granulating / wurster coating, 
      • Dry milling (employing whatever mill is required by your process, generally quadro comil is used), 
      • Bin blending/drum blending /v-blending with optional integrated weighing system in blender (no floor scale required), 
      • High containment to ~400 nano-gram (ETWA) throughout system from initial loading of granulator to final transfer to bin/drum/v-shell.

      Compact Granulation Systems Fluid Bed - High Shear Granulation Compact Granulation Systems Fluid Bed - High Shear Granulation (390 KB)

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    High Shear Granulator P 1 - 6
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    The P 1 - 6 is a laboratory machine for mixing and granulating. The compact bench top version can be set up with minimum space requirements. The bowls are fixed to the basic machine using a simple bayonet system. Allowing them to be easily removed. The machine is operated via a multi function control unit which also provides the ability to modify the settings for simple automated mixing processes. A PC can be connected for reading the process data. Practical, user-friendly bench top version, easy to clean

    • Compact, comfortable and easy to operate,
    • Interchangeable bowls 0.25, 0.5, 1, 2, 4, & 6 litres,
    • PTFE shaft seal, can be dismantled without tools,
    • Transparent vessel lid made from glass or plastic,
    • Variable speed drives – the speed is adjusted to the relevant bowl size,
    • Bowls are optionally available with jacket and temperature measurement,
    • Extensive range of accessories,
    • Bowl changing without tools,
    • Current and power measurement for granulation end point detection with three measuring ranges.

    High Shear Granulators High Shear Granulators (538 KB)

    High Shear Granulator P 100 and 150
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    Diosna pharmacuetical mixers P 100 and P 150 are designed for efficient mixing and wet granulation of tablet masses. The flexible concept behind the P 100 and P 150 are especially suited for pilot plants and small production batches. The systems are offered with a wide range of options for powder and liquid addition. Additionally, we offer many variants for setting up cleaning, control, and integration (such as a built in wet mill on the machine outlet).

    Diosna Pharma Mixers P 100 and P 150 are tailored down to the very last detail to fulfill every practical requirement. Special designs and components for individual applications and needs can be manufactured on request. Diosna has set new standards over the decades thanks to its quality and successful innovations. We continually adapt the design and range of accessories to the requirements of the pharmaceutical industry. If a Diosna standard solution is not sufficient to meet requirements, we develop a customised solution together with the customer, discuss it with us.

    • Permanently-installed mixing bowls,
    • Compact, user-friendly design, with integrated operating terminal,
    • Separate control cabinet with PLC,
    • Pneumatic safety locking for the bowl cover,
    • Stand alone or “through-the-wall” installation,
    • Air purge shaft seals in WIP version (wash-in-place automatic rinsing with water during cleaning),
    • Outlet housing can be opened for cleaning and inspection,
    • In combination with WIP/CIP and high containment valves is suitable for processing potent compounds,
    • Available in version for direct coupling with our CAP fluid-bed dryers.

    Single Pot Processor PVAC 150 - 2000 Single Pot Processor PVAC 150 - 2000 (813 KB)

    High Shear Granulator P 300 - P 1800
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    Diosna mixer-granulators are used by leading companies worldwide and guarantee the safe and reproducible production of high-quality granules – even with most difficult recipes and varying fill volumes.

    The precise construction and robust design allow for small tolerances between bowl base and mixing tool, providing better mixing and product yield. The large mixing blades with enlarged blade tips are positioned tangentially to the central hub. This ensures a good circulation of material even at low speed. The cutting edges of the chopper are positioned in the zone with the highest circumferential speed which causes optimal densification of the granules and precise control of the particle size range. Eventhick products can be mixed and granulated without problems. The special bowl profile allows filling volumes between 30% and 90%. Easy scale up due to identical bowl profiles and the same circumferential speeds of the mixing tool.

    Servolift expertise:

    • Explosion protection, 
    • Installation and integration, 
    • Powder filling systems vacuum / gravity, 
    • Addition of granulation liquid, 
    • Cleaning and cleaning containment, 
    • Control and visualization, 
    • Room layout.

    Single Pot Processor PVAC 150 - 2000 Single Pot Processor PVAC 150 - 2000 (813 KB)

    High Shear Granulator PVAC - 10
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    The P/VAC – 10 is a powerful laboratory machine for a very wide range of applications. It covers the entire bowl capacity of our desktop high shear granulator P 1 - 6, then greatly expands on capability by offering bowl capacity to 10 liters and vacuum drying.

    The machine is especially suitable for users who work with organic solvents or highly active substances, who wish to dry in the mixer (one pot processing) or for those who attach considerable importance to a user-friendly control system with batch data logging. The P/VAC can be offered in an isolator for potent compound processing.

    • Moveable compact machines with integrated control, 
    • Mixing/Granulating bowls for 0,25, 0.5, 1, 2, 4, 6, 8 and 10 liters, 
    • Vacuum drying bowls 2 and 6 litres, 
    • PTFE shaft seal, can be dismantled without a tool, 
    • Transparent vessel lid cover made from glass or plastic, 
    • Vacuum and heating/cooling system can be integrated in the machine, 
    • PLC with operating terminal, 
    • Explosion protection version and integrated industrial PC available, 
    • Easy bowl changing thanks to pneumatically operated chopper coupling, 
    • Optional side discharge port for 8 and 10-l bowls, 
    • Designed for installation in an isolator (glove box), 
    • Available complete with isolator (glove box), 
    • Current and power measurement for granulation end point detection with three measuring ranges.

    High Shear Granulators High Shear Granulators (538 KB)

    High Shear Granulator PVAC 10 - 60
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    The Diosna laboratory mixers P/VAC 10 - 60 are flexible laboratory/pilot scale high shear granulators and granulator vacuum dryers (one pot processor). The machines can be equipped with 10 & 60 liter high shear granulator bowls or 20 & 50 liter vacuum dryer bowls. Different bowls can be added at a later stage. Additionally, a machine initially designed as a high shear granulator can also be extended later to incorporate vacuum drying.

    The vacuum drying bowls are of cylindrical design and equipped with gas-stripping nozzles, the cover is operated pneumatically. One of the main rotor tips is extended to form a scraper to prevent deposits on the bowl wall, as with the production machines. Thus easy scale-up is assured. The “through-the-wall“ setup for a technical zone is included as standard for vacuum drying, as the vacuum pump and heating/cooling device are arranged for set up in a technical area.

    • Moveable compact machine with integrated control,
    • Mixing/Granulating: Interchangeable bowls 10 l, 25 l, 60 l,
    • Vacuum/Gas Stripping (drying): 20 l and 50 l,
    • Easy bowl changing,
    • The drives, outlet and shaft seals remain on the machine when changing the bowls,
    • Air purge shaft seals in WIP version (wash-in-place),
    • Outlet housing can be opened for cleaning and inspection,
    • PLC with operating terminal,
    • Current and power measurement for granulation end point power with different measuring ranges.

    High Shear Granulators High Shear Granulators (538 KB)

    Closed Combined Granulation System 150 - 1800
    supplier logo

    Diosna machines and equipment are used by leading companies worldwide. They are the product of proven reliability and know-how in a wide variety of applications and handling many products.

    Diosna Systems stand for innovative pharmaceutical production equipment of constantly high quality. Diosna offers the principal elements of modern solids production plant - the mixer-granulator and fluid bed dryer - from one source. In our CCS concept these two pieces of equipment are coupled together. This allows optimal arrangement of the production area, and the most effective interfacing.

    Mixers and dryers are matched. The installation can be optimised, and maximum efficiency of the production process is guaranteed. Either vertical or horizontal product flow can be provided. Both pieces of equipment are operated from a common operator interface. Nevertheless each machine remains independent and can be run without the other at any time. Not only does the combination of the items of plant allow completely closed product transfer and the utilization of common cleaning devices but also gives simple and effective controls for the operating and maintenance personnel.

    Closed Combined System CCS 150 - 1300 at a glance.

    • Efficiency: reproducible processes and automated programmes with low set-up times,
    • Safety: individual consideration to ATEX norms of all explosion risks,
    • Through-the-wall-concept: strict separation of production and technical areaContainment conscious design: processing of the product in a closed system, special solutions for highly active substances,
    • From one source: complete range of equipment for materials handling and product preparation,
    • Future-proof: Top-Spray-/ Bottom-Spray-processes in the fluid bed dryer,
    • Qualification: Pharmaceutical industry qualification standards to GAMP 4.

    Closed Combined Fluid Bed - High Shear Granulating Closed Combined Fluid Bed - High Shear Granulating (442 KB)

    Technical Specifications

    The Diosna CGS (Compact Granulation System) is state of the art granulation production in the world's most compact, flexible and integrated plant.

    The CGS system is engineered from the ground up to optimize yield and operator ergonomics. The results are very impressive and have given the Pharmaceutical Industry a new leading standard in excellence of design.

    The CGS system design advantage is in close coupling technology developed by Diosna, which reduces the transfer distances between all processes while optimizing each of those processes though various techniques. The results speak for themselves: higher product yields, easiest access for inspection and cleaning, smallest installation in process room, improved GMPs throughout process train and simplified process. Validation though one highly integrated 21 CFR Part 11 control system.

    Processes offered:

    • Dry mixing/wet granulating/hot melt granulating/vacuum drying (with gas stripping aka "one pot processing"), 
    • Wet calibrating of product (milling) using quadro comil or similar conical screen mill, 
    • Fluid bed drying/top spray granulating/bottom or tangential spray granulating / wurster coating, 
    • Dry milling (employing whatever mill is required by your process, generally quadro comil is used), 
    • Bin blending/drum blending /v-blending with optional integrated weighing system in blender (no floor scale required), 
    • High containment to ~400 nano-gram (ETWA) throughout system from initial loading of granulator to final transfer to bin/drum/v-shell.

    Compact Granulation Systems Fluid Bed - High Shear Granulation Compact Granulation Systems Fluid Bed - High Shear Granulation (390 KB)

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